Millions Take This Popular Supplement – Scientists Discover a Concerning Link to Heart Failure

A large observational study of more than 130,000 adults with chronic insomnia found a possible long-term safety signal for melatonin.

People who used melatonin for over a year had a higher five-year risk of heart failure, heart-failure hospitalization, and all-cause death than similar non-users.

The findings were presented at an American Heart Association meeting and have not yet been peer reviewed.

Because melatonin is widely used as an over-the-counter sleep aid, the results could influence counseling, prescribing, and public health guidance.