A Single Dose of Psilocybin Induces Lasting Brain Changes, New Study Suggests

In a study of 28 psilocybin-naive adults, a single 25 mg psilocybin dose was compared with a low-dose placebo session.

Researchers tracked brain activity with EEG, fMRI and DTI, and found higher brain entropy during the trip was linked to stronger insight.

Participants who reported greater insight also showed better well-being one month later.

The findings suggest that the subjective psychedelic experience may help explain psilocybin’s longer-term mental health benefits.