Researchers Discover Boosting a Single Protein Helps the Brain Fight Alzheimer’s

Researchers found that boosting the astrocyte protein Sox9 increased plaque-clearing activity in an Alzheimer’s mouse model.

The effect worked through MEGF10-dependent phagocytosis, helping astrocytes remove amyloid plaques more effectively.

Mice with existing Alzheimer’s-like symptoms showed reduced plaque buildup and slower cognitive decline.

The findings suggest a new treatment strategy that uses the brain’s own support cells to protect memory.