Poop From Young Mice Reverses Signs of Age-Related Decline in Older Mice

Fecal microbes from young mice restored age-related gut function in older mice.

The transplant boosted intestinal stem cells, Wnt signaling, and epithelial renewal, and improved recovery after radiation injury.

The effect was much weaker in young mice, suggesting aged intestines respond differently to microbiome changes.

Higher Akkermansia levels in aging guts were linked to lower stem cell signaling, pointing to a possible target for gut-repair therapies.