Scientists Discover Metformin Doesn’t Work the Way We Thought

Northwestern University researchers say metformin likely lowers blood sugar mainly in the intestine, not the liver.

Mouse studies suggest the drug boosts glucose use in gut cells and slows mitochondrial activity there.

The findings challenge a long-standing view of metformin’s mechanism and appear in Nature Metabolism.

The work could reshape diabetes research and inspire new treatments that target the gut.