Scientists Discover New Way To Eliminate “Zombie Cells” Driving Aging

Accumulation of senescent (“zombie”) cells drives inflammation, disease, and aging.

Resilience declines as people age and become more frail.

These cells release pro-inflammatory molecules via the SASP that disrupt nearby cells.

Kyoto University researchers found senescent cells rely heavily on glycolysis and show increased PGAM–Chk1 binding at the molecular level.

Using a NanoBiT assay, blocking PGAM–Chk1 binding selectively reduced senescent cell survival, suggesting a way to eliminate them.