This Gene Is Linked to Lower Alzheimer's Risk – And We May Finally Know Why

Researchers found that APOE2 may protect against Alzheimer’s by helping neurons better resist DNA damage and cellular aging.

In stem cell-derived human neurons and mouse studies, APOE2 cells showed less DNA damage, stronger stress repair, and less senescence than APOE3 or APOE4 cells.

The results offer a plausible biological explanation for APOE2’s lower Alzheimer’s risk.

The study also highlights potential new drug targets for preventing or delaying dementia.