Scientists Discover New Way To Make Drug-Resistant Cancer Treatable Again

Scientists identified UNI418, a molecule that weakens cancer DNA repair by lowering IP6 and triggering protein degradation.

UNI418 activates the Cul4A-WDR5 pathway, leading to breakdown of RAD51 and CHK1 and blocking homologous recombination.

The effect restored sensitivity to PARP inhibitors in cancer cells, including some that had become resistant.

The findings suggest a new way to overcome PARP inhibitor resistance by destabilizing repair proteins rather than targeting mutations.