The Hidden Risk of Taking Breaks From Weight-Loss Drugs Like Ozempic

A Penn preclinical study found that stop-start use of semaglutide reduced later weight-loss results in mice.

Animals that paused treatment regained weight during breaks and lost less after restarting than mice on continuous therapy.

The effect appeared linked to changes in body composition, including muscle and fat balance.

The findings suggest GLP-1 drugs such as Ozempic and Wegovy may work best with steady adherence.