Scientists Uncover a Hidden Alzheimer’s Target and Create the First Tool To Control It
TL;DR AI
2 min readKey summary
Vanderbilt researchers developed two new chemical probes for TAOK proteins linked to Alzheimer’s disease.
VU6083859 is the first selective TAOK-1 inhibitor, while VU6080195 unexpectedly activates all TAOK family members.
The compounds were reported in ACS Chemical Neuroscience and are meant as research tools, not medicines.
Scientists hope the tools will clarify TAOK biology in Alzheimer’s and other neurological disorders and aid future drug discovery.