Scientists Discover That a Single Dose of Psilocybin Changes the Human Brain

UCSF and Imperial College London researchers found that a single 25 mg dose of psilocybin changed brain activity and connectivity for weeks.

In 28 healthy volunteers, the drug briefly increased brain entropy, then was followed by more organized neural connections.

People reporting greater emotional insight during the psychedelic experience also tended to show better well-being about a month later.

The results suggest the experience itself may help drive psilocybin’s lasting mental health benefits, with implications for depression, anxiety, and addiction treatment.