Scientists Discover “Molecular Switch” That Fuels Alzheimer’s Brain Inflammation

Scripps Research scientists found that STING becomes overactive in Alzheimer’s disease after S-nitrosylation at cysteine 148.

This SNO-STING change boosted inflammation in human Alzheimer’s cells, patient brain tissue, and mouse models.

Blocking the modification reduced inflammatory damage and helped protect synapses.

The result points to a specific molecular step that could become a drug target to slow neurodegeneration.