Simple “Gut Reset” May Prevent Weight Gain After Ozempic or Wegovy

Early trial results suggest duodenal mucosal resurfacing may help people maintain weight loss after stopping GLP-1 drugs like tirzepatide.

In the sham-controlled REMAIN-1 study, people who had the procedure regained less weight than those who received the fake treatment.

No serious safety concerns were reported, supporting the procedure’s potential as an outpatient option for weight-loss maintenance.

The findings could address a major gap for patients who regain weight after discontinuing medications such as Ozempic and Wegovy.