This “Longevity Gene” May Protect the Brain From Aging and Dementia

A study suggests APOE2 may protect brain cells from DNA damage and cellular aging.

Engineered human neurons with APOE2 showed better genome stability and healthier nuclear structure than APOE3 or APOE4.

In aging mouse brains, APOE2 was also linked to stronger resistance to senescence-related damage.

The findings offer a possible mechanism for APOE2’s association with lower dementia risk and longer lifespan.