Scientists Flip Immune System “Switch,” Uncover Surprising Path To Stop Gut Inflammation

Weill Cornell Medicine researchers found that blocking a T cell co-stimulatory signal in the gut increased RORγt+ regulatory T cells and reduced inflammation.

The result challenges a long-held assumption that this “Signal Two” must be activated to support intestinal immune balance.

The study reveals a new mechanism for gut immune tolerance and may inform future treatments for IBD, Crohn’s disease, and ulcerative colitis.